대구가톨릭대학교 제약공학과

학과소개

교수님 소개

김태환 겸직교수

학력: Ph. D., School of Pharmacy, Sungkyunkwan University; M. Sc., College of Pharmacy, Catholic University of Daegu; B. Sc., College of Pharmacy, Catholic University of Daegu

경력: Post doctoral associate, College of Pharmacy, University of Florida (2017 – 2018); Adjunct professor, School of Pharmacy, Sungkyunkwan University (2016 – 2017); Post doctoral associate, School of Pharmacy, Sungkyunkwan University (2015 – 2017); Senior researcher, Pharmaceutical research institute, Sungkyunkwan University (2015 – 2017); Researcher, Pharmaceutical research institute, Sungkyunkwan University (2012 – 2015)

연구실적

논문: [1] T.H. Kim, S. Shin, S.D. Yoo, B.S. Shin, Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice, Molecules, 23 (2018).; [2] K.Y. Weon, M.G. Kim, S. Shin, T.H. Kim, S.H. Joo, E. Ma, S.W. Jeong, S.D. Yoo, Y.S. Youn, B.S. Shin, Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats, Chin J Integr Med, 24 (2018) 460-466.; [3] C.P. Pires de Mello, X. Tao, T.H. Kim, M. Vicchiarelli, J.B. Bulitta, A. Kaushik, A.N. Brown, Clinical regimens of favipiravir inhibit Zika virus (ZIKV) replication in the Hollow Fiber Infection Model (HFIM), Antimicrob Agents Chemother, DOI 10.1128/AAC.00967-18(2018).; [4] C.P. Pires de Mello, X. Tao, T.H. Kim, J.B. Bulitta, J.L. Rodriquez, J.J. Pomeroy, A.N. Brown, Zika Virus Replication Is Substantially Inhibited by Novel Favipiravir and Interferon Alpha Combination Regimens, Antimicrob Agents Chemother, 62 (2018).; [5] C.B. Landersdorfer, V.E. Rees, R. Yadav, K.E. Rogers, T.H. Kim, P.J. Bergen, S.E. Cheah, J.D. Boyce, A.Y. Peleg, A. Oliver, B.S. Shin, R.L. Nation, J.B. Bulitta, Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model, Antimicrob Agents Chemother, 62 (2018).; [6] C.B. Landersdorfer, R. Yadav, K.E. Rogers, T.H. Kim, B.S. Shin, J.D. Boyce, R.L. Nation, J.B. Bulitta, Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling, Antimicrob Agents Chemother, 62 (2018).; [7] T.H. Kim, S. Shin, J.B. Bulitta, Y.S. Youn, S.D. Yoo, B.S. Shin, Development of a Physiologically Relevant Population Pharmacokinetic in Vitro-in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation, Mol Pharm, 14 (2017) 53-65.; [8] T.H. Kim, S. Shin, S. Kim, J.B. Bulitta, K.Y. Weon, S.H. Joo, E. Ma, S.D. Yoo, G.Y. Park, D.R. Kwon, S.W. Jeong, D.Y. Lee, B.S. Shin, Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine, Molecules, 22 (2017).; [9] T.H. Kim, S. Shin, B.S. Shin, Model-based drug development: application of modeling and simulation in drug development, Journal of Pharmaceutical Investigation, 48 (2017) 431-441.; [10] T.H. Kim, S. Shin, J.C. Shin, J.B. Bulitta, K.Y. Weon, S.D. Yoo, G.Y. Park, S.W. Jeong, D.R. Kwon, B.S. Min, M.H. Woo, B.S. Shin, Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling, Molecules, 22 (2017).; [11] J.B. Bulitta, S.H. Paik, Y.H. Chi, T.H. Kim, S. Shin, C.B. Landersdorfer, Y. Jiao, R. Yadav, B.S. Shin, Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling, Eur J Pharm Sci, 107 (2017) 32-44.; [12] J.B. Lee, A. Zgair, T.H. Kim, M.G. Kim, S.D. Yoo, P.M. Fischer, P. Gershkovich, Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma, J Chromatogr B Analyt Technol Biomed Life Sci, 1040 (2017) 73-80.; [13] J.B. Lee, A. Zgair, D.A. Taha, X. Zang, L. Kagan, T.H. Kim, M.G. Kim, H.Y. Yun, P.M. Fischer, P. Gershkovich, Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays, Eur J Pharm Biopharm, 114 (2017) 38-42.; [14] L.Q. Thao, C. Lee, B. Kim, S. Lee, T.H. Kim, J.O. Kim, E.S. Lee, K.T. Oh, H.G. Choi, S.D. Yoo, Y.S. Youn, Doxorubicin and paclitaxel co-bound lactosylated albumin nanoparticles having targetability to hepatocellular carcinoma, Colloids Surf B Biointerfaces, 152 (2017) 183-191.; [15] S.K. Thapa, K.Y. Weon, S.W. Jeong, T.H. Kim, M. Upadhyay, Y.H. Han, J.S. Jin, S.H. Hong, Y.S. Youn, B.S. Shin, S. Shin, Simple and Rapid Liquid Chromatography-Tandem Mass Spectrometry Analysis of Arctigenin and its Application to a Pharmacokinetic Study, Mass Spectrometry Letters, 8 (2017) 23-28.; [16] T.H. Kim, M.G. Kim, S. Shin, Y.H. Chi, S.H. Paik, J.H. Lee, S.D. Yoo, Y.S. Youn, J.B. Bulitta, S.H. Joo, S.W. Jeong, K.Y. Weon, B.S. Shin, Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats, BMC Pharmacol Toxicol, 17 (2016) 35.; [17] T.H. Kim, M.G. Kim, M.G. Kim, B.S. Shin, K.B. Kim, J.B. Lee, S.H. Paik, S.D. Yoo, Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: Application to ADME studies, Talanta, 144 (2015) 29-38.; [18] T.H. Kim, S.H. Seok, K.B. Kim, B.S. Shin, J.P. Lee, Y.K. Choi, M.G. Kim, M.K. Kim, S.M. Kim, S.D. Yoo, LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats, J Chromatogr Sci, 53 (2015) 1100-1106.; [19] T.H. Kim, S. Shin, K.B. Kim, W.S. Seo, J.C. Shin, J.H. Choi, K.Y. Weon, S.H. Joo, S.W. Jeong, B.S. Shin, Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study, Talanta, 131 (2015) 46-54.; [20] T.H. Kim, S.D. Yoo, H.S. Lee, K.M. Lee, S.H. Seok, M.G. Kim, B.H. Jung, M.G. Kim, B.S. Shin, In vivo absorption and disposition of alpha-cedrene, a sesquiterpene constituent of cedarwood oil, in female and male rats, Drug Metab Pharmacokinet, 30 (2015) 168-173.; [21] T.H. Kim, S. Shin, C.B. Landersdorfer, Y.H. Chi, S.H. Paik, J. Myung, R. Yadav, S. Horkovics-Kovats, J.B. Bulitta, B.S. Shin, Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans, AAPS J, 17 (2015) 1210-1223.; [22] M.G. Kim, T.H. Kim, B.S. Shin, M.G. Kim, S.H. Seok, K.B. Kim, J.B. Lee, H.G. Choi, Y.S. Lee, S.D. Yoo, A sensitive LC-ESI-MS/MS method for the quantification of avobenzone in rat plasma and skin layers: Application to a topical administration study, J Chromatogr B Analyt Technol Biomed Life Sci, 1003 (2015) 41-46.; [23] M.G. Kim, T.H. Kim, B.S. Shin, Y.B. Lee, J.B. Lee, H.G. Choi, Y. Lee, S.D. Yoo, Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of benzyl butyl phthalate and its metabolites, monobenzyl phthalate and monobutyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study, Anal Bioanal Chem, 407 (2015) 7391-7400.; [24] J.B. Lee, B. Shin, S.H. Lee, B.Y. Lee, T.H. Kim, M.G. Kim, S.D. Yoo, Exposure assessment of epidermal growth factor to various tissues in mice after intravenous and subcutaneous administration, J Pharm Pharmacol, 67 (2015) 1519-1527.; [25] J.B. Lee, S.H. Son, M.C. Park, T.H. Kim, M.G. Kim, S.D. Yoo, S. Kim, A novel in vitro permeability assay using three-dimensional cell culture system, J Biotechnol, 205 (2015) 93-100.; [26] T.H. Kim, G.Y. Park, S. Shin, D.R. Kwon, W.S. Seo, J.C. Shin, J.H. Choi, S.H. Joo, K.Y. Weon, B.S. Min, K.M. Baek, M. Upadhyay, B.T. Zhao, M.H. Woo, S.H. Kwon, B.S. Shin, Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats, Evid Based Complement Alternat Med, 2014 (2014) 402126.; [27] T.H. Kim, B.S. Shin, K.B. Kim, S.W. Shin, S.H. Seok, M.K. Kim, E.J. Kim, D. Kim, M.G. Kim, E.S. Park, J.Y. Kim, S.D. Yoo, Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats, J Toxicol Environ Health A, 77 (2014) 202-213.; [28] T.H. Kim, B.S. Shin, S.W. Shin, S.H. Seok, K.-B. Kim, E.J. Kim, D. Kim, D.-H. Kim, W.Y. Yoo, S.D. Yoo, HPLC-MS/MS Method for the Pharmacokinetics of Homosalate after Topical Administration in Rats, Journal of Liquid Chromatography & Related Technologies, 37 (2014) 2465-2477.; [29] T.H. Kim, S. Shin, M. Bashir, Y.H. Chi, S.H. Paik, J.H. Lee, H.J. Choi, J.H. Choi, S.D. Yoo, J.B. Bulitta, E. Ma, S.H. Joo, B.S. Shin, Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats, Xenobiotica, 44 (2014) 913-925.; [30] B.S. Shin, S.D. Yoo, T.H. Kim, J.B. Bulitta, C.B. Landersdorfer, J.C. Shin, J.H. Choi, K.Y. Weon, S.H. Joo, S. Shin, Quantitative determination of absorption and first-pass metabolism of apicidin, a potent histone deacetylase inhibitor, Drug Metab Dispos, 42 (2014) 974-982.; [31] T.H. Kim, S. Shin, J.C. Shin, J.H. Choi, W.S. Seo, G.Y. Park, D.R. Kwon, S.D. Yoo, A.R. Lee, S.H. Joo, B.S. Min, W.Y. Yoo, B.S. Shin, Liquid chromatography-tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study, J Chromatogr B Analyt Technol Biomed Life Sci, 938 (2013) 43-50.; [32] Y. Choi, B.S. Shin, M.G. Kim, S.W. Shin, H.W. Choo, T.H. Kim, H.C. Jang, S.D. Yoo, Micro-sample analysis of capsaicin by liquid chromatography-tandem mass spectrometry assay and application to oral absorption study, Acta Chromatographica, 25 (2013) 363-376.; [33] J.Y. Hong, B.H. Lee, T.H. Kim, J. Hong, K.M. Lee, S.D. Yoo, H.S. Lee, GC-MS/MS method for the quantification of alpha-cedrene in rat plasma and its pharmacokinetic application, J Sep Sci, 36 (2013) 3558-3562.; [34] H.J. Kim, T.H. Kim, W.S. Seo, S.D. Yoo, I.H. Kim, S.H. Joo, S. Shin, E.S. Park, E.S. Ma, B.S. Shin, Pharmacokinetics and tissue distribution of psammaplin A, a novel anticancer agent, in mice, Arch Pharm Res, 35 (2012) 1849-1854.; [35] B.S. Shin, T.H. Kim, S.H. Paik, Y.H. Chi, J.H. Lee, H.K. Tan, Y. Choi, M. Kim, S.D. Yoo, Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography-tandem mass spectrometry, Biomed Chromatogr, 25 (2011) 1208-1214.