대구가톨릭대학교 제약공학과

학과소개

교수님 소개

주상훈 겸직교수

학력: 이학박사 The Ohio State University (미국 오하이오주립대학교) 생화학 전공; 약학석사 서울대학교 대학원; 약학사 서울대학교 약학대학

경력: ACE사업단장, 외국어교육원장, 교무부처장 - 대구가톨릭대학교; 국제위원회 위원장 - 대학약학회; 국제위원회 부위원장 - 대한약사회; 상임이사 - Western Pacific Pharmaceutical Forum; Reserach Associate Duke University Medical Center (미국 노스캐롤라이나); 연구원- 서울대학교 약학대학; 약제과장- 국군수도병원, 국군논산병원; 약제장교- 서부사하라 UN 평화유지활동; 약사- 강남성모병원 (현 서울성모병원)

연구실적

국문 논문: 강동완, 구성민, 박명숙, 주상훈, 2020 세계약사연맹 정책 성명서: 시행 가능한 보수체계를 통한 지속 가능한 약무서비스의 확립, 2020, 대한약국학회지 6(2), 106-113; 주상훈, 신혜원, 나현오, 병원약사의 미래를 위한 바젤성명서(2014 개정문): 약사직무 발전의 방향성, 2018, 대한약국학회지 4(1), 71-77; 주상훈, 방준석, 백경신 세계약학약사연맹(FIP) 서울총회 유치 및 개최 행적을 통해 본 약사의 발전 방향, 2017, 대한약국학회지 3(2), 116-125; 전누리, 심다슬, 주상훈 고용량 비타민D 용법의 메타연구와 비타민D 용법의 지침소개, 2016, 대한약국학회지 2(2), 79-84
저서: 레닌저 생화학 (상, 하), Nelson 외 저, 윤경식 외 공번역, 2018, 월드사이언스; 기초 내분비학, H.Maurice Goodman저, 최윤저 외 공번역, 2013, 월드사이언스

영문 논문: Rajina, S., Kim, W. J., Shim, J. H., Chun, K. S., Joo, S. H., Shin, H. K., Lee, S. Y. and Choi, J. S. (2020). Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells. Int. J. Mol. Sci. 21, 10.3390/ijms21207530.; Choi, J. S. and Joo, S. H. (2020). Recent Trends in Cyclic Peptides as Therapeutic Agents and Biochemical Tools. Biomol. Ther. (Seoul). 28, 18-24.; Park, J. E., Kim, D. H., Ha, E., Choi, S. M., Choi, J. S., Chun, K. S. and Joo, S. H. (2019). Thymoquinone induces apoptosis of human epidermoid carcinoma A431cells through ROS-mediated suppression of STAT3. Chem. Biol. Interact. 312, 108799.; Ma, E., Jeong, S. J., Choi, J. S., Nguyen, T. H., Jeong, C. H. and Joo, S. H. (2019). MS-5, a Naphthalene Derivative, Induces the Apoptosis of an Ovarian Cancer Cell CAOV-3 by Interfering with the Reactive Oxygen Species Generation. Biomol. Ther. (Seoul). 27, 48-53.; Ahn, J., Pei, Y., Chae, H. S., Kim, S. H., Kim, Y. M., Choi, Y. H., Lee, J., Chang, M., Song, Y. S., Rodriguez, R., Oh, D. C., Kim, J., Choi, S., Joo, S. H. and Chin, Y. W. (2018). Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production. Molecules. 23, 10.3390/molecules23020302.; Joo, S. H., Pemble, C. W., Yang, E. G., Raetz, C. R. H. and Chung, H. S. (2018). Biochemical and Structural Insights into an Fe(II)/α-Ketoglutarate/O2-Dependent Dioxygenase, Kdo 3-Hydroxylase (KdoO). J. Mol. Biol. 430, 4036-4048.; Kim, T. H., Shin, S., Kim, S., Bulitta, J. B., Weon, K. Y., Joo, S. H., Ma, E., Yoo, S. D., Park, G. Y., Kwon, D. R., Jeong, S. W., Lee, D. Y. and Shin, B. S. (2017). Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine. Molecules. 22.; Lee, S., Jang, W. J., Choi, B., Joo, S. H. and Jeong, C. H. (2017). 5431587; Comparative metabolomic analysis of HPAC cells following the acquisition of erlotinib resistance. Oncol Lett. 13, 3437-3444.; Joo, S. H. and Chung, H. S. (2016). 5021990; Crystal structure and activity of Francisella novicida UDP-N-acetylglucosamine acyltransferase. Biochem. Biophys. Res. Commun. 478, 1223-1229.; Jeong, C. H. and Joo, S. H. (2016). 4819661; Downregulation of Reactive Oxygen Species in Apoptosis. J Cancer Prev. 21, 13-20.; Kim, T. H., Kim, M. G., Shin, S., Chi, Y. H., Paik, S. H., Lee, J. H., Yoo, S. D., Youn, Y. S., Bulitta, J. B., Joo, S. H., Jeong, S. W., Weon, K. Y. and Shin, B. S. (2016). 4962410; Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats. BMC Pharmacol Toxicol. 17, 35.; Jeong, S. J., Heo, K., Park, J. Y., Lee, K. W., Joo, S. H. and Kim, J. H. (2015). Characterization of AprE176, a fibrinolytic enzyme from Bacillus subtilis HK176. J Microbiol Biotechnol. 25, 89-97.; Joo, S. H. (2015). 4624066; Lipid A as a Drug Target and Therapeutic Molecule. Biomol Ther (Seoul). 23, 510-516.; Kim, T. H., Shin, S., Kim, K. B., Seo, W. S., Shin, J. C., Choi, J. H., Weon, K. Y., Joo, S. H., Jeong, S. W. and Shin, B. S. (2015). Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. Talanta. 131, 46-54.; Jang, W. J., Jung, S. K., Kang, J. S., Jeong, J. W., Bae, M. K., Joo, S. H., Park, G. H., Kundu, J. K., Hong, Y. S. and Jeong, C. H. (2014). 4462346; Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification. Cancer Sci. 105, 1245-1253.; Kim, T. H., Park, G. Y., Shin, S., Kwon, D. R., Seo, W. S., Shin, J. C., Choi, J. H., Joo, S. H., Weon, K. Y., Min, B. S., Baek, K. M., Upadhyay, M., Zhao, B. T., Woo, M. H., Kwon, S. H. and Shin, B. S. (2014). 4229966; Pharmacokinetic alteration of baclofen by multiple oral administration of herbal medicines in rats. Evid Based Complement Alternat Med. 2014, 402126.; Kim, T. H., Shin, S., Bashir, M., Chi, Y. H., Paik, S. H., Lee, J. H., Choi, H. J., Choi, J. H., Yoo, S. D., Bulitta, J. B., Ma, E., Joo, S. H. and Shin, B. S. (2014). Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica. 44, 913-925.; Shin, B. S., Yoo, S. D., Kim, T. H., Bulitta, J. B., Landersdorfer, C. B., Shin, J. C., Choi, J. H., Weon, K. Y., Joo, S. H. and Shin, S. (2014). Quantitative determination of absorption and first-pass metabolism of apicidin, a potent histone deacetylase inhibitor. Drug Metab. Dispos. 42, 974-982.; Kim, T. H., Shin, S., Shin, J. C., Choi, J. H., Seo, W. S., Park, G. Y., Kwon, D. R., Yoo, S. D., Lee, A. R., Joo, S. H., Min, B. S., Yoo, W. Y. and Shin, B. S. (2013). Liquid chromatography-tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 938, 43-50.; Joo, S. H., Chung, H. S., Raetz, C. R. and Garrett, T. A. (2012). Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase. Biochemistry. 51, 4322-4330.; Joo, S. H. (2012). Cyclic peptides as therapeutic agents and biochemical tools. Biomol. Ther. (Seoul). 20, 19-26.; Choi, J. S., Oh, J. I., Na, M., Lee, S. K. and Joo, S. H. (2012). PKCdelta promotes etoposide-induced cell death by phosphorylating Hsp27 in HeLa cells. Biochem. Biophys. Res. Commun. 426, 590-595.; Chae, H., Oh, S., Lee, H., Joo, S. H. and Chin, Y. (2012). Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell. Food Chem. 134, 397-400.; Kim, H. J., Kim, T. H., Seo, W. S., Yoo, S. D., Kim, I. H., Joo, S. H., Shin, S., Park, E. S., Ma, E. S. and Shin, B. S. (2012). Pharmacokinetics and tissue distribution of psammaplin A, a novel anticancer agent, in mice. Arch. Pharm. Res. 35, 1849-1854.; Lee, C. J., Liang, X., Chen, X., Zeng, D., Joo, S. H., Chung, H. S., Barb, A. W., Swanson, S. M., Nicholas, R. A., Li, Y., Toone, E. J., Raetz, C. R. and Zhou, P. (2011). 3149848; Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem. Biol. 18, 38-47.; Guo, Y., Mahajan, A., Yuan, C., Joo, S. H., Weghorst, C. M., Tsai, M. D. and Li, J. (2009). Comparisons of the conformational stability of cyclin-dependent kinase (CDK) 4-interacting ankyrin repeat (AR) proteins. Biochemistry (N. Y. ). 48, 4050-4062.; Liu, T., Joo, S. H., Voorhees, J. L., Brooks, C. L. and Pei, D. (2009). PMC2662701; Synthesis and screening of a cyclic peptide library: discovery of small-molecule ligands against human prolactin receptor. Bioorg. Med. Chem. 17, 1026-1033.; Joo, S. H. and Pei, D. (2008). Synthesis and screening of support-bound combinatorial peptide libraries with free C-termini: determination of the sequence specificity of PDZ domains. Biochemistry (N. Y. ). 47, 3061-3072.; Joo, S. H., Xiao, Q., Ling, Y., Gopishetty, B. and Pei, D. (2006). High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry. J. Am. Chem. Soc. 128, 13000-13009.; Li, J., Muscarella, P., Joo, S. H., Knobloch, T. J., Melvin, W. S., Weghorst, C. M. and Tsai, M. D. (2005). Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Biochemistry (N. Y. ). 44, 13246-13256.; Oh, J. I., Chun, K. H., Joo, S. H., Oh, Y. T. and Lee, S. K. (2005). Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. Cancer Lett. 230, 228-238.; Ham, Y. M., Choi, J. S., Chun, K. H., Joo, S. H. and Lee, S. K. (2003). The c-jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. J. Biol. Chem. 278, 50330-50337.