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학과소개

교수님 소개

이수진 겸직교수

학력
B.S. Seoul National University, School of Pharmacy
M.S. Seoul National University, School of Pharmacy
Ph.D. Seoul National University, School of Pharmacy
경력
Assistant Research Scientist, University of California-San Francisco (2017.7.-2020.8.)
Postdoctoral Researcher, University of California-San Francisco (2013. 7.- 2017.6.)
Postdoctoral Researcher, Research Institute of Pharmaceutical Sciences, Seoul National University (2011. 9.-2013. 6.)

연구실적

논문
1. Chen, X.;Lee, S.; Zhang, T.; Duan, T.;Pasricha, N. D.; Schallhorn, J. M.; Levin, M. H.; Koprivica, V.; Verkman, A. S. "Nanomolar potency aminophenyltriazine CFTR activator reverses coneal epithelial injury in a mouse model of dry eye.” J. Ocul. Pharmacol. Ther. 2020, 36, 147-153.
2. Lee, S.; Cil, Onur; Haggie, P. M.; Verkman, A. S. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J. Med. Chem. 2019, 62, 8330-8337.
3. Haggie, P. M.; Cil, O.; Lee, S.; Tan, T. A.; Rivera, A. A.; Phuan, P. W.; Verkman, A. S. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight 2019, 3, 14.
4. Jin, B.-J.; Lee, S.; Verkman, A. S. Hollow Micropillar Allay Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells. Anal. Chem. 2018, 90, 7675-7681.
5. Lee, S.; Cil, O.; Diez-Cecili, E.; Anderson, M. O.; Verkman, A. S. Nanomolar potency inhibitor of UT-A1. J. Med.Chem. 2018, 61, 3209-3217.
6. Truong, E.C.; Phuan, P.W.; Reggie A.L.; Fererra, L.; Galietta L.J.V.; Levy, S.E.; Moises, A.C.; Cil, O.; Diez-Cecilia, E.; Lee, S.; Verkman A.S.; Anderson M.O. “Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A).” J. Med. Chem. 2017, 60, 4626–4635.
7. Son, J.-H.; Zhu, J. S.; Phuan, P.-W.; Cil, O.; Teuthorn, A. P.; Ku, C. K.; Lee, S.; Verkman, A. S.; Kurth, M. J. “High-potency phenylquinoxalinone cystic fibrosis transmembrane conductance regulator (CFTR) activators.” J. Med.Chem., 2017, 60, 2401-2410.
8. Lee, S.; Phuan, P.-W.; Felix, C. M.; Tan, J.; Levin, M. H.; Verkman, A. S. “Nanomolar-potency aminophenyl-1,3,5-triazine Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride channel activators for pro-secretory therapy of dry eye diseases.” J. Med.Chem., 2017, 60, 1210-1218.
9. Cil, O.; Phuan, P.-W.; Gillespie, A. M.; Lee, S.; Tradtrantip, L.; Yin J.; Tse, M.; Zachos, N. C.; Lin, R.; Donowitz, M.; Verkman, A. S. “Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for anti-secretory therapy of diarrheas caused by bacterial enterotoxins.” FASEB J. 2017, 31, 751-760.
10. Cil, O.; Phuan, P.-W.; Lee, S.; Tan, J.; Haggie, P. M.; Levin, M. H.; Sun, L.; Thiagarajah, J. R.; Ma, T.; Verkman, A. S.” CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation.” Cell.Mol. Gastroenterol. Hepatol., 2016, 2, 317-312.
11. Esteva-Font, C.; Jin, B.-J.; Lee, S.; Phuan, P.-W.; Anderson, M. O.; Verkman, A. S. “Experimental evaluation of proposed small-molecule inhibitors of water channel aquaporin-1.” Mol. Pharmalcol. 2016, 89, 686-693.
12. Lee, S.; Esteva-Font, C.; Phuan, P.-W.; Anderson, M. O.; Verkman, A. S. “Discovery, synthesis and structure-activity analysis of symmetrical 2,7-disubstituted fluorenones as urea transporter inhibitors” MedChemComm, 2015, 6, 1278-1284.
13. Esteva-Font, C.; Phuan, P.-W.; Lee, S.; Su, T.; Anderson, M. O.; Verkman, A. S. “Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters” Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015, 1848, 1075-1080.
14. Cil, O.; Esteva-Font, C.; Tas, S. T.; Su, T.; Lee, S.; Anderson, M. O.; Ertunc, M.; Verkman, A. S. “Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats” Kidney International, 2015, 88, 311-320.
15. Kim, K.; Maharjan, S.; Lim, C.; Kim, N.-J.; Agarwal, V.; Han, Y.-T.; Lee, S.; An, H.; Yun, H. Choi, H.-J.; Kwon, Y. G.; Suh, Y.-G. “Glucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C17-side chai” Eur.J.Med.Chem., 2014, 75, 184-194.
16. Esteva-Font, C.; Cil, O.; Phuan, P.-W.; Su, T.; Lee, S.; Anderson, M. O.; Verkman, A. S. “Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A selective urea transport inhibitors” FASEB J., 2014, 28, 3878-3890.
17. Seo, H.; Yun, H.; Lee, S.; Jang, J.; Han, Y. T.; Kim, D.-D.; Lee, J.; Suh, Y.-G. “Stereoselective synthesis of 7-epi-Incarvilline” Org. Lett., 2013, 15, 531-533.
18. Chang, D.-J.; An, H.; Kim, K.-S.; Kim, H. H.; Jung, J.; Lee, J. M.; Kim,N.-J.; Han, Y. T.; Yun, H.; Lee, S.; Lee, G.; Lee, S.; Lee, J. S.; Cha, J.-H.; Park, J.-H.; Park, J. W.; Lee, S.-C.; Kim, S. G.; Kim, J. H.; Lee, H.-Y.; Kim, K.-W.; Suh, Y.-G. “Design, Synthesis and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis” J. Med. Chem., 2012, 55, 10863-10884.
19. Sim, J.; Yun, H.; Jung, J.-W.; Lee, S.; Kim, N.-J.; Suh, Y.-G. “Achiral auxiliary-assisted chiral transfer via microwave-accelerated aza-Claisen rearrangement: a short synthesis of (+)-1-hydroxyquinolizidinone” Tetrahedron Lett. 2012, 53, 4813-4815.
20. Chang, D.-J.; Lee, S.; Jang, J.; Kim, S.-O.; Kim, W.-J.; Suh, Y.-G. “Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties” Bioorg. Med. Chem. Lett. 2012, 22, 6750-6755.
21. Yun, H.; Kim, J.; Sim, J.; Lee, S.; Han, Y. T.; Chang, D.-J.; Kim, D.-D.; Suh, Y.-G. “Asymmetric Syntheses of 1-Deoxy-6,8a-di-epi-castanospermine and 1-Deoxy-6-epi-castanospermine” J. Org. Chem. 2012, 77, 5389−5393.
22. Han, Y. T.; Choi, G.-I.; Son, D.; Kim, N.-J.; Yun, H.; Lee, S.; Chang, D.-J.; Hong, H.-S.; Kim, H.; Ha, H.-J.; Kim, Y.-H.; Park, H.-J.; Lee, J.; Suh, Y.-G. “Ligand-Based Design, Synthesis, and Biological Evaluation of 2- Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors” J. Med. Chem. 2012, 55, 9120-9135.
23. Lee, S.; Marharjan, S.; Jung, J.-W.; Kim, N.-J.; Kim, K.; Han, Y. T.; Lim, C.; Choi, H.-J.; Kwon, Y.-G.; Suh, Y.-G. “Novel Human Umbilical Vein Endothelial Cells (HUVEC)-Apoptosis Inhibitory Phytosterol Analogues: Insight into Their Structure-Activity Relationships” Arch. Pharm. Res.2012, 35, 455-460.
24. Lee, S.; Paek, S.-M.; Yun, H.; Kim, N.-J.; Suh, Y.-G. “Enantioselective Total Synthesis of a Natural Iridoid” Org. Lett. 2011, 13, 3344-3347.
25. Maharjan, S.; Lee, S.; Agrawal, V.; Choi, H.-J.; Maeng, Y.-S.; Kim, K.; Kim, N.-J.; Suh, Y.-G.; Kwon, Y.-G. “Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy” Eur. J. Pharmacol. 2011, 657, 35-40.
26. Han, Y. T.; Kim, N.-J.; Jung, J.-W.; Yun, H.; Lee, S.; Suh, Y.-G. “A Versatile Synthetic Approach to Grandisol Monoterpene Pheromone” Arch. Pharm. Res. 2011, 34, 1437-1442.
27. Lee, S.; Maharjan, S.; Kim, K.; Kim, N.-J.; Choi, H.-J.; Kwon, Y.-G.; Suh, Y.-G. “Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1” Bioorg. Med. Chem. Lett. 2010, 20, 7102-7105.
28. Han, Y. T.; Paek, S.-M.; Lee, S.; Jung, J.-W.; Jung, J.-K.; Seo, S.-Y.; Lee, J.; Suh, Y.-G. “Thermodynamic equilibration in Pd(0)-catalyzed interconversion of highly constrained [2.1.2] bicyclic lactones: its mechanistic investigation” Tetrahedron Lett. 2010, 51, 2697-2699.
29. Paek, S.-M.; Yun, H.; Kim, N.-J.; Jung, J.-W.; Chang, D.-J.; Lee, S.; Yoo, J.; Park, H.-J.; Suh, Y.-G. “Concise Syntheses of (+)-Macrosphelides A and B: Studies on the Macro-Ring Closure Strategy” J. Org. Chem. 2009, 74, 554-561.

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